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Lipid absorption, distribution, and clearance also were equivalent with genotypes exhibiting identical serum triglyceride kinetics in the absence or presence of tyloxapol (Figure 4, B and C), which inhibits lipoprotein lipase-mediated triglyceride uptake by peripheral tissues ().

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The prohormone signal is selectively decoded in the hypothalamus by proteolytic liberation of uroguanylin, inducing GUCY2C signaling and consequent activation of downstream anorexigenic pathways.(B) H&E staining of representative left liver lobe sections of 12-month-old mice raised on LCD (scale bar: 200 μM).(C) Mean fasted serum leptin concentrations of mice raised on LCD (n = 6–10 per group).Weight differences were also produced by moderate calorie diet (MCD; Supplemental Figure 1A) or high calorie diet (HCD; Figure 1B and Supplemental Figure 1B), primarily composed of carbohydrates or fat, respectively (Supplemental Table 1).

The greatest growth differential was observed in female mice raised on a HCD ( mice was associated with greater accumulation of adipose mass and with increases in the percentage of body weight contributed by fat (adiposity index, Figure 1C), reflecting growth in visceral and subcutaneous fat compartments (Figure 1D).In intestinal epithelial cells, guanylyl cyclase 2C (GUCY2C) is a transmembrane receptor that makes c GMP in response to the paracrine hormones guanylin and uroguanylin, which regulate epithelial cell dynamics along the crypt-villus axis.



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